Posted by yxibow on March 16, 2008, at 20:24:30
In reply to Re: Experiences with Remeron?, posted by Molybdenum on March 15, 2008, at 17:46:41
> I take 225mg mirtazapine - 5 x 45mg tabs every night. I also take venlafaxine.
You're serious ? 225mg mirtazapine is almost 4 times what psychiatrists would prescribe normallyIts way below the LD50 but thats a massive Serotonin surge. I hope your doctor knows what he is doing.
> I have heard too that the sedative action is supposed to be more pronounced at the lower dosages. But for me, it's always helped me to get to sleep - at least for a few months at each new dosage. When it stopped knocking me out at night the the Dr would increase my dose again & again I would get the sedative effect.The sedative and weight gain is rarely more pronounced at lower vs. higher doses, weight gain just increases for the most part.
> He said its not supposed to work that way but it does for me. Unfortunately, I think I'm on the max he'll prescribe now. So when this stops helping me sleep I HAVE NO IDEA WHAT WILL HAPPEN..!
The max I ever was prescribed was 52.5
> Will I need to taper down to nothing over months? All the time not sleeping? I look forward to this NOT.
>
> Anyway, I'm male & 6' tall. I weighed 89kg before I stated taking it. Then I peaked at 110kg. I blame the mirtazapine for that 20kg.
>
> I'm back to 100kg now but I think a lot of people have cravings for sugary things on this drug, so maybe watch out...!It may change metabolism... I certainly got over 100kg, but primarily I think just like Seroquel or Zyprexa or Trazodone for some people it increases appetite
> I remember when I started taking it I got a little sedated the next day. That passed over the first few weeks.
>
> At the height of my sensitivity to it, the good thing was that I could take the tabs at 8pm & be falling on my way to the bed by 9pm. I got a good 10hrs sleep every night. It's been a few years now & although it still helps me to sleep (I've always had trouble), it's nowhere near as powerful as it was in the early days for me.
>
> It's one of the few ADs that isn't supposed to have "sexual" side effects. Just the weight gain & sedation issue.
>
> Good Luck ;)
See one of my postings about sleep disorders -- if you've gotten up to that dose, you may be very tolerant to it -- Trazodone is better for medium term sleep, but it too catches up after a few months or so.Basically to really rid a sleep disorder, one has to sleep with no aids and relax the best one can over a period of a few weeks. But Trazodone would be a better bet.
Now I'm sure you're getting a whopper of antidepressant effect at that dose, I can't imagine how full the 5HTx blockade is.
Good luck
tidings
-- Jay
poster:yxibow
thread:806302
URL: http://www.dr-bob.org/babble/20080316/msgs/818358.html