Posted by bleauberry on March 4, 2008, at 16:52:58
In reply to SULPIRIDE, posted by tensor on March 3, 2008, at 1:35:34
I have not tried sulpride but I have tried the very similar amisulpride. At low doses these block the dopamine autoreceptors (the ones that sense how much dopamine transmission there is). The result is they fire out more dopamine. Theories say more dopamine equals more interest, more motivation, less fatigue, less depression. So if someone has low dopamine, sulpride has good potential since it will stimulate dopamine. At higher doses they begin to block all dopamine receptors. So the dopamine stimulation continues, and yet overexcitation is dampened at the same time. Thus these drugs have shown themselves to be effective for a wide range of symptoms and the doses can be tailored to that.
Since we can't get inside a brain to figure it out, there is no way to know if someone's mood disorder is based primarily in the serotonin system, the norepinephrine system, or the dopamine system. If it is serotonin, sulpride might not be much help. If it is hypodopamine, it could help a ton.
poster:bleauberry
thread:815882
URL: http://www.dr-bob.org/babble/20080303/msgs/816191.html