Re: Lar, SLS, Link: Magnesium blocks Neurontin? » SLS

Posted by Larry Hoover on February 26, 2008, at 21:26:11

In reply to Re: Lar, SLS, Link: Magnesium blocks Neurontin?, posted by SLS on February 26, 2008, at 7:04:20

> Hi.
>
> This is the sort of thing that seems more hypothetical than clinical. Try the Mg and see how it affects you once you have established a stable response to the Neurontin. You know that Neurontin and Lyrica both attach to the alpha2delta subunit of the calcium channel.
Yes, and apparently, magnesium allosterically inhibits gabapentin binding to said subunit of said channel. An allosteric inhibitor changes the shape of the receptor/binding site, without acting in the active site itself.
See:
http://www.ncbi.nlm.nih.gov/pubmed/10760368
http://www.ncbi.nlm.nih.gov/pubmed/12766660
Also, coingestion of gabapentin and magnesium salts inhibits uptake of gabapentin from the gut.
Looks the concern is credible, but it's hard to say how significant it may be.
Lar

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Lar, SLS, Link: Magnesium blocks Neurontin? iforgotmypassword 2/25/08
seems nonsensical, with how effect is at Ca not Mg (nm) iforgotmypassword 2/26/08
Re: Lar, SLS, Link: Magnesium blocks Neurontin? SLS 2/26/08
Re: Lar, SLS, Link: Magnesium blocks Neurontin? » SLS iforgotmypassword 2/26/08
Re: Lar, SLS, Link: Magnesium blocks Neurontin? » SLS Larry Hoover 2/26/08

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