Posted by Jamal Spelling on February 24, 2008, at 11:08:31
In reply to Re: Dopamine receptor antagonists » yxibow, posted by Jamal Spelling on February 24, 2008, at 9:09:17
This is not what I was hoping to see.
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Eur Neuropsychopharmacol. 1997 Nov;7(4):261-6.Click here to read Links
Tolerability of low dose neuroleptics: a case control study of flupenthixol.
Fritze J, Spreda I.Klinik für Psychiatrie und Psychotherapie I, Zentrum der Psychiatrie, Johann Wolfgang Goethe-Universität, Frankfurt am Main, Germany.
There are no data available on the risk of extrapyramidal symptoms when using long-term flupenthixol in low dosage in patients suffering from anxiety and depressive disorders. In a case control study 106 patients essentially treated with the neuroleptic flupenthixol in a so-called low, non-antipsychotic dosage were compared to n=37 otherwise comparable patients who never had been treated with neuroleptics. The investigator was blind to the previous treatment conditions. Extrapyramidal symptoms were found although with a low prevalence and mild degree: 6.7% tardive dyskinesia, none in controls; pseudoparkinsonism 26%, 16% in controls. Extrapyramidal side-effects, especially tardive dyskinesia, have to be considered in the individual weighing of therapeutic benefits and risks even when prescribing flupenthixol in low dosages.
PMID: 9443657 [PubMed - indexed for MEDLINE]
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poster:Jamal Spelling
thread:814286
URL: http://www.dr-bob.org/babble/20080221/msgs/814406.html