Posted by Larry Hoover on February 3, 2008, at 14:54:11
In reply to Re: no luck with Emsam... what next?, posted by former trx resistant on February 2, 2008, at 22:22:18
> As we all know our brains are wired quite individually. But as to seizures, I don't know what you found reading up on Wellbutrin but listen to TV ads-what they tell you is biggest most common risk - seizures. I was told >than 1 in a thousand.
> That is very high when you think of the millions on this drug. My dr. says just within his small group of patients he had, within weeks of my episode he had 3 other patients have same thing. different ages & genders. That's >than 1 in 1000!!! I have no family history, quite healthy, about 45 when it happened.The seizure threshold is reduced by Wellbutrin in a dose-dependent fashion. Wellbutrin will give anybody seizures, if the dose is high enough. At 300 mg/day, the risk is 0.1%. At 450 mg/day, the risk is 0.4% (4 per 1,000). At 600 mg/day, the risk is 2.3% (23 per thousand; based on t.i.d. dosing). The increase in risk is exponential with dose. Those who take it (immediate release format) b.i.d. are probably more likely to seize than these numbers suggest. Extended release preparations would presumably be similar to t.i.d. dosing.
The 1 in 1,000 risk only applies to 300 mg/day dosing.
Lar
poster:Larry Hoover
thread:809787
URL: http://www.dr-bob.org/babble/20080124/msgs/810538.html