Posted by sdb on February 2, 2008, at 16:56:29
In reply to Re: Beta Blockers and Depression, posted by sdb on January 31, 2008, at 9:38:06
> > Thank you to those that have replied.
> >
> > Larry, I have not tried going completely off of the Atenolol yet, but am going to try this. I have recently been going through a trial of Wellbutrin which has been overly stimulating even at the low dose of 50mg per day (only on this for a little over a week). I am going to discuss going off of the WB and then working to discontinue the Atenolol. The Atenolol has done a good job with the physical effects, but I now believe may be adding to my problem.
> >
> > Thanks again!
>
> To lower the bloodpressure there are other medications than betablockers that some people tolerate better (more compliance). For anxiety issues only a 12.5mg-25mg nadolol (isn't mebabolized which is a plus if people take more than one medication) could help but as stated does not take any anxiety feelings away. Anxiety is actually a 'normal' feeling to some degree.
>
> There is some information I wrote quite recently:
>
> a betablocker does not take the anxiety away. But it can be beneficial in the way that you're much more willing to provoque yourself with a certain situation. Nadolol is one betablocker with some benefits compared to propranolol. Nadolol's chemical structure is very similar to propranolol but it differs by having a hydrophile substitute. People with migraine often use nadolol as prophylaxis. It isn't metabolized by the liver and penetrates the blood-brain barrier in extremely little portions. It's half-life is 24h and there is some accumulation over some days. Maybe 10mg-40mg a day.
>
> warm regards
>
> sdb
>
> http://www.ncbi.nlm.nih.gov/pubmed/6148877?ordinalpos=10&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
> PMID: 6148877
>
> http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=7847498
> http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=29207655
>
> http://www.dr-bob.org/babble/20071225/msgs/803147.htmlbetablockers still do have its place to lower bloodpressure to a lesser degree than other meds, to lower portal hypertension, to treat arrhythmias, angina pectoris or eg. connective tissue disorders by lowering the afterload, shear stress and following dilation of some bigger blood vessels.
a PFO (a little hole in the atrial septum of the heart) could be a reason for headaches (migraine).
atenolol and nadolol are both found in the liquor cerebrospinalis. nadolol only in tiny portions. blocking brain and peripheral beta-receptors can be a reason for its depressogenic properties. It can make somebody tired, the heart contracting less vigorously. Every betablocker is somehow different , some betablockers very seldom induce depression.
poster:sdb
thread:809406
URL: http://www.dr-bob.org/babble/20080124/msgs/810340.html