Posted by SLS on January 18, 2008, at 20:48:02
In reply to Re: Bias in publishing of antidepressant trials? » SLS, posted by Larry Hoover on January 18, 2008, at 18:51:21
Hi Larry.
> > My impression is that this behavior has been condoned by the FDA for many years such that it became accepted as standard practice by the pharmaceutical companies.> Hey Scott. As I understand it, it's irrelevant to the FDA. They want to see all research, as part of their approval process. Should we extend FDA control over the publication industry?
Good point.
> I saw an interesting question raised, with respect to a possible confound to this review of publication bias. How likely are journals to publish failed trials?I guess it's not sexy enough.
> Unless they determine whether these negative trials were submitted for publication, then this study is itself biased.
I think I understand what you are saying. I guess articles submitted to peer-reviewed journals are subject to the reviewers' determining the effectiveness of the trial reported. A failed study would be judged to be ineffective, and therefore has no reason to be published.
- Scott
poster:SLS
thread:807465
URL: http://www.dr-bob.org/babble/20080114/msgs/807505.html