Posted by Phoenix1 on January 17, 2008, at 8:43:25
In reply to Re: Thanks!, posted by Jamal Spelling on January 17, 2008, at 7:31:13
> > > Does anyone have any thoughts on low dose flupentixol? It's a typical thioxanthene AP.
> > >
> > > Does anyone know the difference between sulpiride and amisulpride? They are both benzamide APs, apparently very similar. It seems many have used amisulpride, but what about sulpiride? Can it, too, be used to counteract anhedonia, possibly alongside and SSRI?
> >
> > Hi Jamal,
> >
> > Take a look at this:
> >
> > http://www.dr-bob.org/cgi-bin/pb/mget.pl?post=/babble/20041123/msgs/420491.html
> >
> > And these:
> >
> > http://www.ncbi.nlm.nih.gov/pubmed/15738862
> > http://www.biopsychiatry.com/amisulpride.htm
> > http://www.biopsychiatry.com/amisulpridedop.htm (NOTE: Specifically talks about dopaminergic deficiency with is associated with anhedonia.)
> >
> > And this:
> >
> > http://www.biopsychiatry.com/sulpiride.htm
> >
> > So I have no idea if amisulpride is superior to sulpride. Most of the literature on depression is on amisulpride, not sulpride. Both appear to be affective, fairly safe augmenters or primary drugs for minor anhedonia. I'm pretty sure they can be used with an SSRI, although there is no literature that I can find to support this. Seems amisulpride is used as the primary agent and has been shown to have similar efficacy to SSRI's in some studies. Although look at this:
> >
> > http://www.dr-bob.org/cgi-bin/pb/mget.pl?post=/babble/20020416/msgs/103469.html#103469
> >
> > Maybe a bad idea to combine? Just try amisulpride trial? Do a search on low dose flupentixol. I think there's some lit on it as an AD but don't have time to look it up for.
> >
> > I hope this is more helpful than confusing, but I fear it may be the latter. Happy to talk to you any time on these topics. Fascinating to me!
> >
> > Phoenix1
> >
>
> Thanks for your detailed and informative response.
>
> Years ago, I was on a combination of Zoloft and low dose (< 1mg/day) flupentixol, with reasonable results. Not sure if it did much for my mood, but sure helped me feel alive and calm. I enjoyed listening to music for example; now I just feel dead. Everything feels boring.
>
> Side-effects of the flupentixol were:
> - non-permanent hair loss (no kidding). My hair fell out substantially while using it; this problem ended when I stopped the flupentixol;
> - weight gain, of the order 10kgs, in the sense that, when I stopped the flupentixol, I lost about 10kgs in just a few months. Still don't know how that worked, because my diet didn't really change.
> - I needed more sleep, although I was perfectly alert while awake. So I didn't find it sedating as such, I just needed more sleep. And boy, was it good sleep!
>
> I actually have a theory, which I cannot prove of course, that long-term use of Zoloft may have permanently affected my ability to experience pleasure.Hi Jamal,
Glad you found the links interesting. I have a strong healthy fear of SSRIs after trying most of them with no positive results. I believe that one of them may have semi-permanently worsened my anxiety. Just an opinion, as many people see to do well on SSRIs and have no problems discontinuing. Maybe some of us do have permanent side effects though.
Anyways, the amisulpride thing is really interesting. It appears to be very different from the classic APs but also significantly different from the atypical AP's. I'm not sure if you could replicate it's antidepressant effects by using any other AP. I'd love to give it a try if Nardil weren't working so well. Something to keep in the back of my head in case I need a new AD for some reason. Not many choices left after what I've tried.
Phoenix1
Phoenix1
poster:Phoenix1
thread:806974
URL: http://www.dr-bob.org/babble/20080114/msgs/807193.html