Posted by amigan on January 13, 2008, at 17:53:41
In reply to Re: Selegiline (l-deprenyl) made me SLEEPY!.. » amigan, posted by mav27 on January 13, 2008, at 16:28:38
> > You are right. This is what i read on another thread here, while i was searching. It could be that i have too many or too sensitive dopamine AUTO-receptors. Also, i have tried l-dopa in the past and all it did, was to make me vomit.
> > I wonder if there is any way to overcome this by Blocking the auto-receptors?? Any suggestions are welcome.
>
> Amisulpride will block d2 autoreceptors at low dose (under 100mg). Bocking autoreceptors increases dopamine transmission.
>
> I'm on it at the moment, so far for me it's had a sort of calming yet activating effect, and has helped with my social anxiety quite well but it doesn't feel very strong, on the plus side no side effects at all other than a couple hours less sleep than usual.Good idea. I have read that sulpiride and amisulpride have this property at low doses. I have only tried sulpiride in the past because it's cheaper. Have you ever tried it in order to be able to compare these 2 meds?
My experience with sulpiride is, more or less, like yours with amisulpride: A calming (not sure about activating) effect, which was VERY weak. Hardly distinctable from placebo.. And that was the main reason that made me to stop taking it.
I have had some mild side effects, but only in the beginning.
Is Amisulpride any better? If it is, i might give it try.
poster:amigan
thread:805921
URL: http://www.dr-bob.org/babble/20080105/msgs/806233.html