Posted by Jedi on December 31, 2007, at 2:38:33
In reply to Re: Parnate available-Phoenix1, posted by Justherself54 on December 28, 2007, at 9:52:44
Hi,
Nardil has kept my major depression away for most of the past eleven years. I've stopped it four times for trials of newer meds with maybe less side effects. Each time this has resulted in the return of my major depression. Major side effects that are still with me; weight gain, insomnia(treated with Seroquel), presbyopia, delayed orgasm, and daytime somnolence. I will live with these over major depression. Each of my major depressions has been life threating.You are right. The medical term for "poop out" is tachyphylaxis.
Take care,
Jedi
Medical Dictionary - tachyphylaxis
Definition:
Rapid appearance of progressive decrease in response to a given dose after repetitive administration of a pharmacologically or physiologically active substance.
------------------------------------------
> It took a few weeks for the insomnia to really manifest itself. Will your pdoc let you hold on to one benzo for bedtime? I hope the insomnia doesn't happen, but I think more often than not it does. My pdoc and I decided to try MAOI's, hoping to get more than 6 months or a year at best as every single med has pooped out on me..when I see people post on here that have been on it for 20 years with no poop out, it gives me hope.
>
> I don't know the medical term for poop out, other than I think it might be called serotonin fatigue and I found another term on the web called tachyphylaxis. Good luck to you!
>
>
> > Yikes, that's not good to hear. On the other hand, I've now heard the full spectrum of how people respond to Nardil so I will just have to wait and see how it affects me. My pdoc started me on an escalating dose: 15mg for 3 days, 30mg for 3 days, 45mg for a week, then 60mg for a week. The end goal depending on how I respond is 1mg/kg, per published literature. That would mean a 90mg dose. My insomnia is already bad, and my pdoc is tapering me off benzos completely, so I don't know what to expect. I have very high hopes that Nardil will help me. My only previous MAOI experience with Moclobemide was a huge but very short lived success.
> >
> > BTW, any ideas on how to prevent the dreaded Nardil poop-out before it happens? Is their a medical term for "poop-out" for lit searches?
> >
> > Thanks,
> >
> > Phoenix1
> >
> > > > Interesting that your insomnia was worse on >Nardil than on Parnate. I'd always heard the >reverse was more common.
> > > >
> > > > Phoenix1
> > >
> > > I thought insomnia couldn't get worse than when i was on parnate... boy was i wrong.. nothing will ever compare to how bad Nardil caused me insomnia when i was on it recently.
> >
> >
>
>
poster:Jedi
thread:802726
URL: http://www.dr-bob.org/babble/20071225/msgs/803380.html