Posted by linkadge on December 28, 2007, at 23:04:20
In reply to Re: SSRI sex dysfunction - 5ht2a receptors - expla, posted by Jimmyboy on December 26, 2007, at 17:00:15
I don't think it is completely mediated by reduction in CNS dopaminergic neurotransmission. I remember reading about some involvement of the 5-ht2c receptors (in the lower brainstem or something) controling ejaculatory threshold or something.
The SSRI's affect both the desire, and the capacity. Ie you can take a drug like amphetamine, caffiene, etc and regain some of the desire yet still have genital anesthesia or anorgasmia etc.
There are other possible causes too like perhaps the SSRI's lowering growth hormone via 5-ht1d receptor desensitzation etc. Acetylcholine is also involved in certain phases of sexual responce/desire, so indirect anticholinergic effects might be involved.
Linkadge
poster:linkadge
thread:802173
URL: http://www.dr-bob.org/babble/20071225/msgs/803102.html