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Need Help..How do you switch from SERZONE to SSRI

Posted by garyengelm on December 16, 2007, at 17:32:09

I've been on Serzone 200mg bid for 4 years. I've tried to wean Serzone, but I get severe Akasthasia even just reducing 25mg. This last year, I've tried adding low doses of several SSRI's. The Serzone has pooped out and when I add say 1.25mg of Lexapro, I feel good for the first few days, but then I go into pre-Seratonin Syndrome, or so it seems. I get severe nausea with gagging, chills, body aches, diarrhea, rumbling stomach, literally on the couch all day in fron of the fireplace. Even adding 1.25mg of Lexapro to the Serzone does this and it has happened with celexa, and zoloft. All the symptoms go away after stopping the SSRI within 24hours. I feel stuck, as the Akatasia I get when I go down just a little bit on the Serzone is also unbearable. I feel like I'm gonna crawl out of my skin, my anxiety feels like I had 50 cups of cappachino and I can't sit still or think right. If I add the 25mg back to my system, I'm better within an hour.

The Serzone blocks the 5HT2A receptor, which helps anxiety, and I'm pretty sure, the decrease in dosage does something there. Not sure about the norepinephrine blockage is also part of the equation.

So, I'm thinking, if I could either make a complete switch or just go down on the Serzone and replace it with anohter SSRI, it might work. But if I'm on 400mg of Serzone, then what is the equivalent of Lexapro, or Zoloft, etc. I'm so sick of this crap, thank god for Xanax, whcih does nothing for the Akasthasia when it comes on.

Appreciate any input.

Gary


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poster:garyengelm thread:801159
URL: http://www.dr-bob.org/babble/20071213/msgs/801159.html