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Chromium picolinate (another study)

Posted by Jedi on December 3, 2007, at 13:21:00

In reply to Re: What causes weight gain with Nardil? » Marty, posted by Jedi on December 3, 2007, at 13:09:11

Biol Psychiatry. 2003 Feb 1;53(3):261-4. Effectiveness of chromium in atypical depression: a placebo-controlled trial.Davidson JR, Abraham K, Connor KM, McLeod MN.
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA.

BACKGROUND: Chromium picolinate (CP) has been reported to benefit patients with symptoms of atypical depression. METHODS: A placebo-controlled, double-blind, pilot study of CP was conducted in 15 patients with DSM-IV major depressive disorder, atypical type. Patients received 600 micro g of CP or matching placebo (PBO) for 8 weeks. RESULTS: Seven (70%) CP and zero (0%) PBO patients met responder criteria (p =.02). Other outcomes were consistent with greater effect of CP. Three patients on CP failed to show any improvement. Chromium picolinate was well tolerated. CONCLUSIONS: Chromium picolinate shows promising antidepressant effects in atypical depression. Its mechanism of action may relate to 5HT2A downregulation, increased insulin sensitivity, or to other effects.

PMID: 12559660 [PubMed - indexed for MEDLINE]


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