Posted by tecknohed on November 18, 2007, at 8:51:44
In reply to It's a good thing!, posted by Astounder on November 16, 2007, at 8:36:14
> Less NET pumps = Less NE/tyramine/octopamine/DA uptake into NA terminals. This is similar to the action of tertiary amine tricyclics and SSRIs on SERT. It's probably responsible for the plastic, curative (not palliative) effects of antidepressants, why you can often remove the drug after remission and still maintain their effects. Opposite, drugs you develop tolerance to, like DAT blockers, increase the number of DAT pumps, making them less effective over time.
Makes sense, thanks.
poster:tecknohed
thread:794573
URL: http://www.dr-bob.org/babble/20071115/msgs/795721.html