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I started Anafranil (clomipramine) yesterday » clubfitter

Posted by Astounder on November 15, 2007, at 20:20:02

In reply to Anyone using Tricyclics for Depression?, posted by clubfitter on November 11, 2007, at 14:14:52

25 mg. Increased to 50 mg next week. My psych says it works well for obsessive symptoms (which result for me in avoidance), and that it's effects on this are immediate. I WAS able to look at my face uncritically in the mirror this morning, which IS unusually non-avoidant. I was however, terribly akathitic, tense, and chilled, similar to the feeling of taking Effexor with Selegiline. Onle problem with clomipramine is that I won't be able to augment with an MAOI.

I tried desipramine for a month, adding it onto Namenda (10 mg) high doses EmSam (21 mg) and Remeron (90 mg). When I kicked the desipramine up to 100 mg, I started getting frank visual hallucinations, and at 25 mg aural hallucinations. This was really surprising to me, as I've taken high doses of cyproheptadine, Benadryl, doxylamine, and scopolamine before, but never had anything like that--especially since desipramine is supposed to be the kindest with regard to mACh affinity. I figure it was an enzymatic issue.

Desipramine didn't really add on anything; no extra energy/anti-avoidance like I hoped, and I was continuing to have terrible REM issues.

> I am so doped up right now with little relief. Am considering about asking my doctor about MAOI's or Trycyclics. Has anyone had success with Tricyclics, which ones, and how fast acting are they. Thanks in advance. MDD, AVPD, SAD, etc....maybe bipolar, mostly unipolar depression
>
> 20 lexapro
> 400 lamictal
> 300 wellbutrin
> 160 geodon

Nortrip looks like a good add on, since it's heavily NAergic, which would potentiate the SSRI and DAergic effects of wellbutrin. Also might help you sleep at night. You'll develop a tolerance to that effect, though. Or instead you might take the Wellbutrin up to 600 mg if you're sleeping too much.


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poster:Astounder thread:794414
URL: http://www.dr-bob.org/babble/20071115/msgs/795351.html