Posted by Astounder on November 2, 2007, at 16:27:44
In reply to Re: Dopamine agonists cause sedation. But why??, posted by linkadge on November 2, 2007, at 15:08:36
> That depends. It is not a strong 5-ht1a antagonist which means that some symptoms of serotonin syndrome can still occur namely hyothermaia.
Hypothermia is not a normal symptom of the serotonin syndrome. Do you mean hyperthermia?
Animal studies indicate that hyperthermia from serotonin syndrome is mediated entirely through 5-HT2a receptors:
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=11164765&ordinalpos=9&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=10867971&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlusRitanserin, pipamperone, and risperidone are highly selective for the 5-HT2 series over 5-HT1a, and risperidone is 5-HT2a selective over 5-HT2c.
5-HT1a may be responsible for some of the behavioral symptoms, though.
There are clinical studies in humans proving the safety of a MAOI with Elavil:
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=6342565&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlus
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=7435677&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlus> Yeah and 5-ht2b agonsts are what is responsible for cardiac hypertrophy and valve dammage. Probably why to avoid all SSRI's.
SSRIs actually reduce plasma and platelet 5-HT levels with chronic use, though, so they shouldn't cause cardiac fibrosis. Unrelatedly, because 5-HT induces platelet aggregation, SSRIs are thrombolytic in vitro, and there are ongoing studies to determine if SSRIs reduce the risk of infarction and stroke.
poster:Astounder
thread:791344
URL: http://www.dr-bob.org/babble/20071027/msgs/792998.html