Posted by Larry Hoover on October 29, 2007, at 7:40:13
In reply to Poorly absorbed meds: Alternative method?, posted by Amigan on October 27, 2007, at 20:45:42
> Hello.
> Take sulpiride as an expample. It is poorly absorbed, clorazepate which has unstable absorption and many others.
> Does anyone know if snorting or let them melt under the tongue will lead to better absorption into the bloodstream?
> Which of the 2 methods gives the best result?I wouldn't recommend snorting anything.
If you can stand the taste, sublingual tissues do allow for direct transfer of some drugs into the circulation, but that is dependent on solubility. Highly soluble drugs tend to have higher uptake overall, so the main advantages of sublingual uptake are speed of entry into the circulation, and avoidance of first pass metabolism. I don't think either of these benefits addresses your question.
Dosing recommendations already take into account uptake/bioavailability. Are you trying to save money?
Lar
poster:Larry Hoover
thread:791864
URL: http://www.dr-bob.org/babble/20071027/msgs/792114.html