Posted by Ron Hill on October 26, 2007, at 23:23:34
In reply to Keep posting successes on deplin or methylfolate, posted by stargazer2 on October 26, 2007, at 21:50:49
Star,
> I have TRD and need to knowif this is something that might help me. I just told my pdoc about it today and he thinks it may be worth trying.I'd say, give it a try. L-methylfolate is endogenous in your brain already. Deplin just raises the level of L-methylfolate substantially. Side effects are rare, but Deplin can cause insomnia, irritability and a few other things. If it doesn't work for you, simply discontinue it.
I find that 7.5 mg/day is not enough for me. I take 7.5 mg first thing in the morning with the rest of my meds. I can feel the Deplin working about 15 minutes after taking it. However, it begins to wane after about six hours. So, I take another 7.5 mg dose about six hours after taking the morning dose.
The dose-response curve for the plasma level of 6(S)-MTHF (Deplin) verses time is presented at the bottom of this web page:
http://www.deplin.com/HealthcareProfessionals,DeplinPlease notice that at the six hour mark, the plasma level of Deplin is only about a fourth of what it is at the peak. My hunch is that this is why I need a second dose at about the six hour mark.
For those interested, here is the document from which this dose-response curve was originally taken: http://www.nature.com/bjp/journal/v141/n5/pdf/0705446a.pdf
Stargazer, remember that I have only been taking Deplin for five days. And, although I am getting absolutely excellent results so far, it is way too early to know if the benefits will last. Time will tell.
Research followed by trial-and-error is the name of the game when it comes to finding the p-meds that work the best for each particular patient.
-- Ron
Bipolar II with ultra rapid cycling (15 day cycle), and mild Obsessive Compulsive Personality Disorder (OCPD)
600 mg/day Trileptal
200 mg/day Lamictal
875 mg/day Keppra
90 mg/day Nardil
15 mg/day Deplin
poster:Ron Hill
thread:790747
URL: http://www.dr-bob.org/babble/20071019/msgs/791676.html