Posted by Netch on October 10, 2007, at 9:27:24
In reply to Antidepressants and bleeding, posted by amigan on October 10, 2007, at 8:59:21
1.
“Among the 196 persons in the study admitted to the hospital with abnormal bleeding, the risk of hospitalization increased with the use of the strongest SSRI antidepressants - that is, those that produce the most inhibition of serotonin reuptake. The risk of being hospitalized for bleeding was twice as high in drugs that produce intermediate inhibition, and about 2.6 times as likely for the drugs that produce high degrees of inhibition.”
Antidepressants with Intermediate Effects:
Venlafaxine (Effexor) - Atypical
Dothiepin (Prothiaden) - Tricyclic
Amitriptyline (Elavil) - Tricyclic
Fluvoxamine (Luvox) - SSRI
Imipramine (Tofranil) - Tricyclic
Citalopram (Celexa) - SSRIAntidepressants with High Effects
Paroxetine (Paxil) - SSRI
Clomipramine (Anafranil) - Tricyclic
Sertraline (Zoloft) - SSRI
Fluoxetine (Prozac) - SSRIIt is important to note that this one study found that less than 1% of its participants developed bleeding difficulties. While those now taking these antidepressants certainly need to be aware of this possibility, there is no need for alarm.
http://bipolar.about.com/od/antidepressants/a/antidepbleeding.htm
2.
The risk of bleeding from TCA/SSRI is less compared to aspirin:
"The researchers analysed 24 previous studies of aspirin, involving almost 66,000 patients.
They found that, on average, bleeding occurred in 2.5% of patients taking aspirin compared with 1.4% who were not. "
http://news.bbc.co.uk/1/hi/health/1014089.stm
3.
Yes, I believe so
"Alderman et al. (28) in their conclusions acknowledge the possibility that abnormal platelet function is more likely to occur when high doses of SSRIs are administered, which is in agreement with the time- and dose-dependent inhibition of platelet release reactions found in the present study. "
http://ajp.psychiatryonline.org/cgi/content/full/162/6/1165
/Netch
poster:Netch
thread:788221
URL: http://www.dr-bob.org/babble/20071009/msgs/788228.html