Posted by UGottaHaveHOPE on September 28, 2007, at 11:45:58
In reply to Re: Help! Your opinion? I messed up on Nardil » UGottaHaveHOPE, posted by tecknohed on September 26, 2007, at 15:06:34
TH:
It has been two weeks at 45mg, and Im not sure it has completely kicked back in. Thanks for your information below, it is very valuable.
Did you ever go off Nardil and get back on? Any experiences you have to share would be great. Thanks, Michael.
> > During the summer, I was feeling better on Nardil at 45mg/day. I went out of town and left it at home for three days. Since I still felt fine, when I resumed taking it, I did at 15mg per day rather than 45. And I guess I did OK on 15mg for about 6-8 weeks.
> >
> > THEN some life stressors hit me (moving), and I have not been able to handle it too well. My anxiety, which had seen its lowest levels in years, is peaking again.
> >
> > I told my pdoc about going from 45 to 15mg. He was disappointed that I had adjusted without communication with him, and he instructed me to go from 15 to 45mg.
> >
> > He said it would take 2-3 weeks to feel it, after going from 15 to 45mg. Anyone else have any guesses or experiences on doing the same thing? How long do you think it will take to kick in again?
>
> Here's my theory:
> You say its your anxiety causing most problems at the mo? One of Nardils metabolites, PEH (phenylethylidenehydrazine), raises GABA but (I think) only to levels in relation to your Nardil dose. So the more Nardil you take the better the anxiolytic effect will be (within normal dosing ranges of course).
>
> But Nardil (may) only need a low maintainance dose for depression alone, which might be why 15mg/day has been enough until now. Thats because once you've 'knocked out' MAO with the higher dose only a small dose is needed to keep MAO inhibited thus relieving depression.
>
> Now your anxiety has increased but there isn't enough PEH (Nardil's main metabolite) in your system for the desired anxiolytic effect.
>
> I think you'll see an improvement sooner than your doc thinks, at least I hope you do.
>
> Just a theory mind! Get well soon.
poster:UGottaHaveHOPE
thread:785314
URL: http://www.dr-bob.org/babble/20070919/msgs/785720.html