Posted by Phillipa on September 13, 2007, at 20:31:38
In reply to Doxylamine, posted by saturn on September 13, 2007, at 18:42:28
I thought you were talking about an antibiotic . Here's what I found no haven't tried it hope some one has. Phillipa
Doxylamine
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Doxylamine
Systematic (IUPAC) name
N,N-dimethyl-2- (1-phenyl-1-pyridin-2-yl-ethoxy)- ethanamine
Identifiers
CAS number 469-21-6
ATC code R06AA09
PubChem 3162
DrugBank APRD00937
Chemical data
Formula C17H22N2O
Mol. mass 270.369 g/mol
Pharmacokinetic data
Bioavailability ?
Metabolism Hepatic
Half life variable; 6–12 hours
Excretion ?
Therapeutic considerations
Pregnancy cat. ?
Legal status OTC
Routes Oral
Doxylamine succinate is one of the many sedating antihistamines used by itself as a short-term sleep aid, in combination with other drugs as a night-time cold and allergy relief drug, and a preparation is prescribed in combination with vitamin B6 (pyridoxine) to prevent morning sickness in pregnant women.Contents [hide]
1 Indications
2 Formulations
3 Side effects
4 External links
[edit] Indications
Doxylamine is a member of the ethanolamine class of antihistamines and has anti-allergy power superior to almost every other antihistamine on the market, with the exception of diphenhydramine (Benadryl).[citation needed] It is also the most effective over-the-counter sedative available in the United States[citation needed], and more sedating than some prescription hypnotics. In a study, it was found that doxylamine succinate is possibly more effective than the barbiturate phenobarbital for use as a sedative.[citation needed] For this reason, doxylamine has sometimes been used off label in a manner similar to diphenhydramine for the reduction of anxiety symptoms.The dosage required to induce hypnosis (sleep) can be as low as 6.25 mg, but is usually effective in dosages of up to 25 mg. Higher doses are not recommended by the United States Food and Drug Administration, although single dosage recommendations of up to 50 mg are common in countries like Australia, where it is marketed under the names Restavit and Dozile.
[edit] Formulations
It is one of the active ingredients in NyQuil.
In Commonwealth countries, such as Australia, Canada, and the United Kingdom, doxylamine is available prepared with paracetamol (acetaminophen) and codeine under the brand name Syndol or Mersyndol, as treatment for tension headache and other types of pain.
Doxylamine succinate is used in general over-the-counter sleep-aids branded as Somnil, Donormyl, DSozile, Restavit and Unisom-2.
In the United States doxylamine succinate is the active ingredient in the over-the-counter sleep-aid tablets branded as Unisom.
It is also available in combination with vitamin B6 and folic acid under the brand name Evanorm (marketed by Ion Healthcare).
In Canada, doxylamine succinate and pyridoxine(vitamin B6) are the ingredients of Diclectin, which is used to prevent morning sickness.[edit] Side effects
Doxylamine succinate is a potent anticholinergic and has a side-effect profile common to such drugs, including dry mouth, ataxia, urinary retention, and drowsiness. Other drugs with well known anticholinergic effects include many antipsychotic and tricyclic antidepressant drugs.
poster:Phillipa
thread:782727
URL: http://www.dr-bob.org/babble/20070911/msgs/782747.html