Posted by cumulative on August 28, 2007, at 23:37:02
In reply to Re: EMSAM with transdermal nicotine for ADD contro » cumulative, posted by Quintal on August 28, 2007, at 0:24:52
Not a smoker. I've been using gum on and off with not much effect besides nausea if I keep it in my mouth too long, but my hopes are still high. I've responded decently to patches in the past.
Tolerance could definitely be an issue. Someone told me, though, that nicotine will activate stimulant reverse tolerance for dopamine. There haven't really been any long-term studies on the effectiveness of the stuff for ADD/ADHD, I think.
Cost: Cost is high. Now, in a brilliant marketing stroke the high-dose patches cost the same as the low-dose patches, so I might just buy 21mg patches in bulk and cut them for a while. I hear though that this can expose the patches to air and destroy some of the nicotine, but maybe there's a way to properly store the cut patches so this doesn't occur?
What might be useful is an elucidation of some more of the neurochemistry of nicotine.
Can someone explain the functional differences to me between an acetylcholinesterase inhibitor and nicotine, which stimulates nicotinic acetylcholine receptors (causing downstream release of catecholamines)? Am I getting more acetylcholine activity, or is (as one person said I think) the nicotinic acetylcholine receptor actually opposed in some ways to regular ACh ...?
Here's hoping it works. If it doesn't, I'll probably be f*cking up a class I'm really looking forward to, and maybe another six months of not really connecting with people at my new school. If it doesn't work, next step might be the Daytrana patch ... plus aricept.
poster:cumulative
thread:779241
URL: http://www.dr-bob.org/babble/20070824/msgs/779450.html