Posted by Quintal on August 17, 2007, at 21:34:08
In reply to Re: Beta-carbolines and benzos, posted by psychobot5000 on August 16, 2007, at 15:20:37
>Also, re: coffee as an antidote for alcohol--people have been using it that way for a long time, certainly, but I think the beta-carboline research is interesting because health teachers and drug warriors and the like have been insisting, for decades, that coffee doesn't help you sober up in any way.
Well the next time you talk to one of them you can just show them this study :-)
____________________________________________________1: Life Sci. 1988;42(18):1765-72.Links
The benzodiazepine receptor inverse agonists beta-CCM and RO 15-3505 both reverse the anxiolytic effects of ethanol in mice.
Belzung C, Misslin R, Vogel E.Laboratoire de Psychophysiologie, Strasbourg.
The antagonistic effects of the benzodiazepine receptor inverse agonist beta-CCM (1 mg/kg) and of the partial inverse agonist RO 15-3505 (3 mg/kg) on the anxiolytic properties of ethanol (1 g/kg) in mice confronted with a light/dark choice procedure and with the staircase test were investigated. Both drugs reversed the effects of ethanol on some of the behavioral parameters, but beta-CCM alone elicited anxiogenic intrinsic effects. RO 15-3505 induced seizures in mice treated with a subconvulsant dose of pentylenetetrazole, the most efficient doses being 3 and 6 mg/kg. These data indicate that beta-CCM and RO 15-3505 can reverse some of the anxiolytic effects of ethanol, acting probably to oppose GABA function via the benzodiazepine receptor.
PMID: 2896286 [PubMed - indexed for MEDLINE]
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poster:Quintal
thread:776629
URL: http://www.dr-bob.org/babble/20070815/msgs/776861.html