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Re: desvenlafaxine vs. venlafaxine + uptake ratio ? » linkadge

Posted by Larry Hoover on August 11, 2007, at 20:23:55

In reply to desvenlafaxine vs. venlafaxine + uptake ratio ?, posted by linkadge on August 11, 2007, at 19:56:54

> Anyone have any information of whether desvenlafaxine differs to any appreciable extent from venlafaxine in terms of ratio of affinity for monoamine uptake pumps?
>
> Venlafaxine elevated my blood pressure but was a reasonable AD. Would desvenlafaxine be any different?
>
> Linkadge

According to the data I just looked at, they have virtually identical inhibition at 5-HT, and NE, but desvenlafaxine is substantially weaker at the dopamine transporter. I found no desvenlafaxine data for adrenergic/muscarinic receptors.

Lar

 

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poster:Larry Hoover thread:775569
URL: http://www.dr-bob.org/babble/20070808/msgs/775573.html