Posted by linkadge on August 2, 2007, at 15:14:09
In reply to Nix on the Anafranil..., posted by Racer on August 2, 2007, at 13:43:23
TCA's can also cause hypertention. I was on a high dose of clomipramine without effect on blood pressure. I had some increase in heart rate but thats all.
Also, TCA's vary in their propensity to cause weight gain. Doxapin and Amitryptaline are the most likely to do so. These two are strong antagonists at 5-ht2c.
Clomipramine isn't a 5-ht2c angatonist, and therefore probably a indirect agonist. I found it decreased appetite similar to effexor. It felt like a much more tollerable version of effexor.
Its your decision, and YMMV, but in terms of a strong antidepressant, and anti-OCD, with less apathy inducing effects clomipramine is a good option, and you never know unless you try.
I personally think that any drug which creates apathy is much more likely to lead to weight gain. On clomipramine I was very active and did a lot of hiking and running. I probably lost weight, although I don't need that.
Linkadge
poster:linkadge
thread:773349
URL: http://www.dr-bob.org/babble/20070730/msgs/773576.html