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Re: lamotrigine - anyone on 800 mg/day? » Keith Talent

Posted by Bonnie_CA on July 29, 2007, at 9:31:27

In reply to lamotrigine - anyone on 800 mg/day?, posted by Keith Talent on July 29, 2007, at 3:40:27

> Currently on 400 mg/day (split into 2 doses) for a bipolar spectrum disorder. Only been on this dose for a week, so too early to tell if it will help. My psychiatrist is going to keep me on this dose for 6 weeks, then either increase it to 800 or add lithium (probably at 1.2 mEq/L).
>
> As for the posts re lamotrigine memory impairment, this drug was developed for epilepsy in the (erroneous) belief that folate increased the likelihood of seizures. So yes, it does have an anti-folate action, but this has nothing to do with its antiepileptic/mood stabilizing properties. It would be interesting to see a double-blind, randomized controlled trial on the effects of folate supplementation on memory/cognition in patients on lamotrigine (or has this been done already?).
>
>

Wow, that is a lot of Lamictal! But, everyone is different. Can you explain why folate impairs memory for patients on Lamictal? I don't understand.

-Bonnie


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poster:Bonnie_CA thread:772668
URL: http://www.dr-bob.org/babble/20070719/msgs/772686.html