Posted by linkadge on July 26, 2007, at 18:25:31
In reply to Re: can we talk Typical Antipsychotics? » big time, posted by Squiggles on July 26, 2007, at 17:59:58
>I would think we have become a little more >specialized now
Not in my opinion. Have you read the CATIE study? Large study done by the NIMH. Essentially said that atypicals were no more effective for negative symptoms or positive symptoms than the comparitor typical AP, perphenazine. They also mentioned that the side effect profile was different though not necessarily better. The older drug, perphenazine was not associated with more movement issues, or metabolic issues.
See:http://www.nimh.nih.gov/healthinformation/catie_qa.cfm
Contrary to expectations, movement side effects (rigidity, stiff movements, tremor, and muscle restlessness) primarily associated with the older medications were not seen more frequently with perphenazine than with the newer drugs. The advantages of olanzapine — in symptom reduction and duration of treatment — over perphenazine were modest and must be weighed against the increased side effects of olanzapine.
Thus, taken as a whole, the newer medications have no substantial advantage over the older medication used in this study. An important issue still to be considered is individual differences in patient response to these drugs.
Linkadge
poster:linkadge
thread:772161
URL: http://www.dr-bob.org/babble/20070719/msgs/772186.html