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Re: SSRI brain damage - To Linkadge » Deniseuk190466

Posted by linkadge on July 23, 2007, at 13:58:14

In reply to Re: SSRI brain damage - To Linkadge, posted by Deniseuk190466 on July 23, 2007, at 13:22:22

Good question.

I think its got to do with the fact that TCA's block the 5-ht2/3 receptors in addition to their effects on monoamine uptake. Kind of like combining a SSRI with an atypical antipsychotic.

The problem is that while activation of certain serotonin receptors may promote placticity during stress, the activation of others may actually exacerbate stress induced hippocampal morphology.

For instance, activation of 5-ht3 & 5-ht2 receptors can cause anxiety and neurotransmitter release. Blocking these receptors may not only enhance the antidepressant effect of serotonergic compounds, but can also possably do more to prevent such alterations.

For instance, 5-ht2a antagonists alone, can prevent stress induced hippocampal restructurization.


Thats just what I gather.

Linkadge


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