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Re: amantadine also linked to cardiac valve damamg

Posted by kingcolon on July 11, 2007, at 10:54:35

In reply to Re: amantadine also linked to cardiac valve damamge, posted by linkadge on June 30, 2007, at 10:04:38

I have been on Requip recently, and when I read the article on possible problems with the non-ergot derivatives causing mitral valve tenting, I too was concerned. I actually stopped the Requip (unfortunately it was helping me and there really are no alternatives in this class of direct dopamine agonists that I know of).
Bromocriptine may be free of 5HT2 agonism, but it has not been very effective overall, and little testing in using it for depression.
We are left with amphetamine itself, and since I"ve had some abuse history, this isn't appropriate for me.
I'm not surprised that so little has been discussed of these findings with nonergot compounds since they are a mainstay in the treatment of Parkinson's.
Thanks for the input.


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