Posted by Larry Hoover on June 29, 2007, at 6:47:41
In reply to Re: Nothing suggests Vitamin b destroys Nardil » GWA, posted by Honore on June 28, 2007, at 23:16:26
> In other words, nardil and the other compounds named antagonize, or destroy, vitamin b. Nothing says that vitamin 6 destroys nardil. Nothing in this article or anywhere that I could find, at least.
From GWA's post:
" PDRHealth says of B6 that 'Phenelzine may react with pyridoxal 5'-phosphate to yield a metabolically inactive hydrazone compound'."It is precisely this phrase that led me to state earlier in the thread that phenelzine concentration might also be reduced by B6. The sole functional group on phenelzine is the hydrazine moiety. If the chemical reaction with pyridoxine converts it to a hydrazone, it is no longer able to inactivate the reactive centre of monoamine oxidase. It is rendered physiologically inert.
Obviously, if true, this reaction must take place in all individuals taking phenelzine, as everybody has some amount of pyridoxine in their tissues. It would be a dynamic balance, dependent on reactant concentrations, and it could be shifted into disequilibrium in either direction.
The underlying assumption is that this mechanism explains the B6 deficiency in susceptible individuals. Individual differences in genetic (or environmental, e.g. dietary) factors might relegate it to an insignificant concern, or elevate it to a dominant regulatory position.
Lar
poster:Larry Hoover
thread:765488
URL: http://www.dr-bob.org/babble/20070622/msgs/766640.html