Posted by linkadge on June 21, 2007, at 8:04:04
In reply to Re: scopolamine trial for depression » linkadge, posted by Bob on June 20, 2007, at 20:22:58
I really don't know. The MAOI's will lower cholinergic tone by increasing the monoamines. The TCA's are direct anticholinergics as well as indirect anticholinergics by affecting the monoamines.
The SSRI's will pull the serotonergic/cholinergic axis in favor of serotonin, and some are direct anticholinergics (paroxetine). Bupropion has some anticholinergic effects. Remeron does too, as it can supress REM sleep, and REM behavioral disorder.
Even 5-ht1a partial agonists reduce cholinergic release.
Even tianeptine reduces cholinergic activity through some unidentified mechanism.
The mood stabilizers lithium and valproate seem to work the opposite. They enhance the responsiveness of the cholinergic system.
If you feel that meds are really messing up your system, try to get down to the lowest possable dose and eat as healthy as possable for a while.
Even margiannly inadequate nutrition can impair the speed of the ongoing adjustements made to such systems.Linkadge
poster:linkadge
thread:764244
URL: http://www.dr-bob.org/babble/20070613/msgs/764692.html