Posted by psychobot5000 on June 9, 2007, at 0:37:44
In reply to Re: amitryptaline and ketamine patch » deniseuk190466, posted by Quintal on June 8, 2007, at 17:51:45
There's a subtle difference between oral selegiline and the Emsam patch though, but I've forgotten what it is. Someone else will probably know.
>
> QAccording to my source, the difference is less subtle than you might think. If you filter selegiline through first pass liver metabolism (by taking it in pill form), it produces high levels of various types of amphetamine (l-amphetamine, d-amphetamine, l-methamphetamine, if I remember right). Which isn't all bad, but is perhaps a different effect than you're looking for. As selegiline has a shorter halflife than amphetamines, within a number of hours, the parent drug's blood levels drop very low, but significant numbers are left over for amphetamine metabolites.
With EMSAM, you deliver a much higher level of the parent drug, the blood-levels are fairly stable, and because you avoid first-pass metabolism by not going through the stomach, levels of amphetamine metabolites are much lower. It's a different effect.
Psychbot
PS. I wasn't under the impression that ketamine was a practical option for antidepressant therapy - more a research lead. Well, maybe not!
poster:psychobot5000
thread:761877
URL: http://www.dr-bob.org/babble/20070604/msgs/761953.html