Posted by bravohr98 on June 8, 2007, at 10:12:52
In reply to Grapefruit and Zoloft experiment, posted by bravohr98 on June 8, 2007, at 6:06:57
Also, I forgot to mention one more important thing:
Yesterday when I took grapefruit juice i did not take zoloft. I forgot to fill in my prescription so I was without zoloft for that whole day.This actually seems VERY important since grapefruit is said to raise the concentration of drugs by inhibiting CYP3A4 in intestines and liver.
But in my case that could not have happened because I did not take any sertraline that day. Sertraline has approx. 26 hrs drug half life so I only had 1/2 in my system that day.I found some web pages that say there is also some amount of CYP3A4 in the brain. They still dont really know what is its role in the brain but maybe it aslo works in the same way it works in the liver and gut.
My theory is that grapefruit may have blocked the CYP3A4 in the brain effectively raising the sertraline availability in the neurons - this is the only logical explanation.
It could not have raised the blood levels since my last dose of zoloft was some 30 hrs before grapefruit consumption. Sertraline is known to have big first pass metabolism witch happens within few hrs after dosing. I dont think that sertraline blood concentration could have been raised in my case since there was a big time gap from this first pass metabolism.
poster:bravohr98
thread:761798
URL: http://www.dr-bob.org/babble/20070604/msgs/761819.html