Posted by psychobot5000 on June 5, 2007, at 22:59:01
In reply to Re: Guanfacine XR Significantly Improved ADHD Symptoms, posted by linkadge on June 5, 2007, at 21:05:40
> interesting. Still doesn't resolve why a NRI could treat ADD and a drug like this that essentially lowers noradrenergic neurotransmission would also work.
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> LinkadgeStrange, isn't it? Researchers seem to be proposing that Guanfacine selectively acts on alpha-2a receptors, present in the brain and which help regulate some aspects of alertness and focus. Thus, while guanfacine lowers noradrenaline levels overall through its action on alpha 2 receptors, it also has some direct action on awareness that more than compensates. That's how I understand it, anyway.
I suppose this helps put it in the position of being useful for relieving anxiety (in some people who find stimulants exacerbate it) and boosting attention at the same time.
Psychbot
poster:psychobot5000
thread:761347
URL: http://www.dr-bob.org/babble/20070604/msgs/761443.html