Posted by Jedi on May 5, 2007, at 15:40:47
In reply to Can you take Parnate and Nardil at the same time?, posted by Malcolm64 on May 5, 2007, at 11:29:05
> I wanted to ask something that I don't believe has been discussed before: what about taking Parnate and Nardil at the same time? Obviously, the doses would need to be adjusted to safe levels, but I'm just wondering if these two meds can be combined safely to get more "bang for the buck" if you will. That way the strengths of each drug would be combined to deliver maximum effectiveness.
> Has anyone ever tried this before and has it helped?
> I realize I may be grasping at straws here, but I thought I'd ask.
> MalcolmMalcom,
Here is some of the research:Ann Pharmacother. 1992 Mar;26(3):337-8.
Central nervous system toxicity after abrupt monoamine oxidase inhibitor switch: a case report. Safferman AZ, Masiar SJ.
Hillside Hospital, Division of Long Island Jewish Medical Center, Glen Oaks, NY.DESCRIPTION: There have been numerous case reports of adverse reactions involving monoamine oxidase inhibitors (MAOIs), including reactions that developed when one MAOI was substituted for another. Although most reports have usually described a switch from isocarboxazid or phenelzine to tranylcypromine, we report a case of acute central nervous system toxicity possibly associated with a switch from phenelzine to isocarboxazid. SYMPTOMATOLGY: Predominant symptoms included stuporous sensorium, hypertension, tachycardia, tremor, and urinary retention. Onset of symptoms began within 48 hours after the abrupt MAOI switch. CONCLUSIONS: Clinicians must allow a sufficient washout period before adding any agent that has a known potential to interact adversely with MAOIs. In addition, patients who are unusually sensitive to one type of MAOI may also be at increased risk for developing problems with a different MAOI secondary to unforeseen pharmacokinetic or pharmacodynamic effects, even at doses that are usually considered subtherapeutic.
PMID: 1554951 [PubMed - indexed for MEDLINE]
J Clin Psychiatry. 1998 Jul;59(7):382.
Stroke resulting from a rapid switch from phenelzine to tranylcypromine. Mattes JA.
PMID: 9714269 [PubMed - indexed for MEDLINE]
poster:Jedi
thread:754919
URL: http://www.dr-bob.org/babble/20070502/msgs/756104.html