Posted by linkadge on April 23, 2007, at 14:09:50
In reply to Re: Article: mood/ocd research with abused drugs, posted by nellie7 on April 23, 2007, at 13:12:50
Not necessarily. The anti-OCD effects of these drugs would likely take place at much lower doses than are used to have psychedeic effect.
Many of the psychedellics are potent 5-ht2a/c receptor agonists.
It is believed that the anti-OCD effects of SSRI's are mediated (in part) by agonism of 5-ht2a/c receptors.
Certain psychedellics could theoretically target these receptors with less effect on other receptor subtypes.
THe 5-ht2a/c receptors mediate gabergic responces in the frontal cortex. By activating these receptors one may help ameliorate the pathological frontal cortex activity that one sees in OCD.
So no, there may actually be some theraputic utility to these drugs, beyond their recreactional effects.
Linkadge
poster:linkadge
thread:752704
URL: http://www.dr-bob.org/babble/20070419/msgs/752747.html