Posted by Larry Hoover on April 21, 2007, at 14:39:06
In reply to Re: Drugs metabolized by the liver, posted by Squiggles on April 21, 2007, at 13:49:45
> Thank you for taking the time to answer.
> "Comatose" is only a transient initial state,
> gradually turning to sedation, to sleep, to
> relaxation and then awake. (3 hrs. post K injestion).
>
> Thanks again. Could be the interaction/dose.
>
> Squiggles
>Just to be clear, there is a liver interaction. Both drugs are processed by liver enzyme 3A4. There is also a functional interaction, as both drugs have sedating qualities.
The way you manage these is by adjusting dose. That includes managing one dose to zero, if necessary. I reiterate, comatose is not a reasonable drug effect. It's all about quality of life, not ability to suffer through it.
Lar
poster:Larry Hoover
thread:744916
URL: http://www.dr-bob.org/babble/20070419/msgs/752041.html