Posted by jealibeanz on April 14, 2007, at 12:57:52
In reply to Re: ocinaplon... gone for good?, posted by Tom Twilight on April 14, 2007, at 11:44:04
> I fear it is :(
>
> GABA partial agonists look so promising, it infuriating that none have made it to the market.
>
> I wonder how difficult it is so synthasise?Yeah, it's disappointing. I researched a little and found some information about why this drug is no longer being studied. Apparently it caused significant changes in liver enzyme levels, which is an indicator of disease/damage.
So it looks like it was pulled for a good reason. Otherwise, it probably would have been released and promoted as the latest and greatest medication, since it reduces anxiety without the sedation and impairment of benzodiazepines. If it were prescribed long-term in high doses, 10 years from now there might have been a lot of very unhappy patients suffering from liver disease.
It's not like this is the only drug to cause an increase in liver enzymes. Some have more of an impact on the liver than others.
This makes me wonder if benzodiazepines have this same effect. It seems like they were very similar in structure. People don't normally have blood tests run regularly because they're taking medication. So most of us have no idea if a particular drug is causing physiological changes.
poster:jealibeanz
thread:749708
URL: http://www.dr-bob.org/babble/20070413/msgs/749783.html