Posted by Quintal on March 31, 2007, at 14:12:03
In reply to Re: Dopamine Agonists, posted by linkadge on March 31, 2007, at 13:35:14
I was just thinking of amineptine actually, it wasn't associated with the kind of euphoria Ritalin and amphetamines usually produce (although it did have abuse potential). I'm starting to associate high dopamine with mellow contentment than speedy euphoria, but perhaps a sudden increase in dopamine can cause a 'rush'? It seems that most of the euphoric dopaminergic drugs bar opiates are also powerful NA reuptake inhibitors.
I'm thinking of experimenting with adding a NRI agent to see if that helps focus and motivation. I have reboextine and sibutramine and I'm thinking sibutramine might have additional benefits on the serotonin system, but it's also a little 'messier' than reboextine. I think I'll try reboxetine first, is there any interaction info/problems between these drugs?
>It depends on the brain region involved. Dopamine agonists do not necessarily bind with high affinity to reward regions whereas a non region specific DRI will activate such regions.
Is it possible to create a dopamine agonist that binds directly to receptors in the nucleus accumbens? I want one!
Q
poster:Quintal
thread:745429
URL: http://www.dr-bob.org/babble/20070327/msgs/745765.html