Posted by yxibow on March 22, 2007, at 2:43:26
In reply to Orofacial dyskinesias and dystonia in rats infecte, posted by iforgotmypassword on March 21, 2007, at 3:15:46
> **Orofacial dyskinesias and dystonia in rats infected with Borna disease virus; a model for tardive dyskinetic syndromes.**
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> huh? this does not sound good. does this mean that a potentially widespread virus in humans may be causing a range of antidopaminergic pathologies were not really discussing very actively?
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> Mol Psychiatry. 1999 Jul ;4 (4):310-2 10483043
> Orofacial dyskinesias and dystonia in rats infected with Borna disease virus; a model for tardive dyskinetic syndromes.
> [My paper] M Solbrig , G Koob , W Lipkin
> The neurochemical and lesion effects of Borna disease virus infection in rats result in a syndrome with phenotypic and pharmacological similarities to tardive dyskinesia.
The potentiality of "widespread" Borna disease has not been proven yet, and has some controversy over it. Yes, it is in the family of Rabies, Ebola, Newcastle, etc, but if we go down the road of blaming the existence of an illness on every virus and environmental cause, we may also miss the very true possibility that in fact most all long term psychiatric disorders are genetic at least in part.
Acta Neuropsychiatrica 15 (5), 262–265, a study of 62 hospitalized schizophrenic patients from three hospitals with deficit syndrome did not find BDV transcripts in their systems.
This isn't to say that some disorders have at least in part been caused by a virus -- rarely, some forms of OCD have been identified to have their original etiology caused by a virus rather than pure genetic disposition.
poster:yxibow
thread:742723
URL: http://www.dr-bob.org/babble/20070320/msgs/743101.html