Posted by rjlockhart on March 9, 2007, at 18:39:59
In reply to Amphetamine is a releaser not a reuptake inhibitor, posted by notfred on March 9, 2007, at 18:29:49
Because methylphenidate and amphetamines are by far the most widely used agents for ADHD, most treatment-refractory patients will have already tried at least one of them. However, Dr. Wilens noted that methylphenidate and amphetamines exert their effects via somewhat different mechanisms: Methylphenidate binds fairly selectively to the dopamine transporter (thereby blocking reuptake) but does have some affinity for the norepinephrine transporter; amphetamines block reuptake of dopamine and norepinephrine as well but, more importantly, also facilitate release of these neurotransmitters from presynaptic storage granules. These mechanistic differences may explain why a patient who doesn’t respond to methylphenidate may benefit from amphetamine, and vice versa.
http://www.neuropsychiatryreviews.com/march02/adhd.html
There where some more out there i am still looking up............i was on this, well i researched amphetamines 2 years so, im just now starting to rerember what i've posted back in time.
My old screen name was rjlockhart98.
poster:rjlockhart
thread:739475
URL: http://www.dr-bob.org/babble/20070308/msgs/739618.html