Posted by psychobot5000 on February 25, 2007, at 11:31:49
In reply to What is the longest lasting TCA for sleep?, posted by starfox on February 24, 2007, at 13:07:09
> I was just wandering what tricyclic AD had the longest half life with regards to sleep?. From what I understand Doxepin Is very good at making you fall asleep but is there another tricyclic that would be better for actually keeping you asleepI think Doxepin might indeed be the best, but trimipramine/surmontil is very similar, and (I gather) may have a longer half-life in some people(though slightly less sedation from H1 blocking, presumably). So that might be better for a few. Also, Remeron has a similar H1 blocking effect to doxepin, and a longer half-life(something like 33 hrs) than either of them. The disadvantage, I find, was its residual sedation during the day.
Though Remeron is usually thought of as an 'atypical' AD, I believe it is actually a tetracyclic in structure, with some pharmacalogical similarities to TCAs.
poster:psychobot5000
thread:735773
URL: http://www.dr-bob.org/babble/20070224/msgs/736011.html