Posted by Quintal on February 18, 2007, at 16:17:01
In reply to Re: Why Most New Antidepressants Are Ineffective » Quintal, posted by linkadge on February 18, 2007, at 16:05:24
Yup, here is a wiki article and some studies showing the effectiveness of Agnus Castus in lowering prolactin levels in women with premenstrual problems:
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The berries are considered a tonic herb for both the male and female reproductive systems. The leaves have the same effect, but to a somewhat lesser degree. It is used in some supplements for male bodybuilders as a secondary component, as some studies suggested that it may decrease the prolactin levels, which, in turn, increases LH (luteinizing hormone)and testosterone levels. It has been assumed to not have the same effect on the female hormonal balance, but recent studies contradict this.
http://en.wikipedia.org/wiki/Vitex_agnus-castus
__________________________________________________Since AC extracts were shown to have beneficial effects on premenstrual mastodynia serum prolactin levels in such patients were also studied in one double-blind, placebo-controlled clinical study. Serum prolactin levels were indeed reduced in the patients treated with the extract. The search for the prolactin-suppressive principle(s) yielded a number of compounds with dopaminergic properties: they bound to recombinant DA2-receptor protein and suppressed prolactin release from cultivated lactotrophs as well as in animal experiments. The search for the chemical identity of the dopaminergic compounds resulted in isolation of a number of diterpenes of which some clerodadienols were most important for the prolactin-suppressive effects. They were almost identical in their prolactin-suppressive properties than dopamine itself. Hence, it is concluded that dopaminergic compounds present in Vitex agnus castus are clinically the important compounds which improve premenstrual mastodynia and possibly also other symptoms of the premenstrual syndrome.
PMID: 12809367 [PubMed - indexed for MEDLINE]
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=12809367&query_hl=2&itool=pubmed_docsum
__________________________________________________Treatment for the premenstrual syndrome with agnus castus fruit extract: prospective, randomised, placebo controlled study.Schellenberg R.
Institute for Health Care and Science, 35625 Huttenberg, Germany. med@t-online.deOBJECTIVES: To compare the efficacy and tolerability of agnus castus fruit (Vitex agnus castus L extract Ze 440) with placebo for women with the premenstrual syndrome. DESIGN: Randomised, double blind, placebo controlled, parallel group comparison over three menstrual cycles. SETTING: General medicine community clinics. Participants: 178 women were screened and 170 were evaluated (active 86; placebo 84). Mean age was 36 years, mean cycle length was 28 days, mean duration of menses was 4.5 days. INTERVENTIONS: Agnus castus (dry extract tablets) one tablet daily or matching placebo, given for three consecutive cycles. MAIN OUTCOME MEASURES: Main efficacy variable: change from baseline to end point (end of third cycle) in women's self assessment of irritability, mood alteration, anger, headache, breast fullness, and other menstrual symptoms including bloating. Secondary efficacy variables: changes in clinical global impression (severity of condition, global improvement, and risk or benefit) and responder rate (50% reduction in symptoms). RESULTS: Improvement in the main variable was greater in the active group compared with placebo group (P<0.001). Analysis of the secondary variables showed significant (P<0.001) superiority of active treatment in each of the three global impression items. Responder rates were 52% and 24% for active and placebo, respectively. Seven women reported mild adverse events (four active; three placebo), none of which caused discontinuation of treatment. CONCLUSIONS: Dry extract of agnus castus fruit is an effective and well tolerated treatment for the relief of symptoms of the premenstrual syndrome.
PMID: 11159568 [PubMed - indexed for MEDLINE]
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?itool=abstractplus&db=pubmed&cmd=Retrieve&dopt=abstractplus&list_uids=11159568
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poster:Quintal
thread:733613
URL: http://www.dr-bob.org/babble/20070213/msgs/733903.html