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Re: increased obsessiveness on folate n other Bvit » yxibow

Posted by Larry Hoover on February 15, 2007, at 9:36:00

In reply to Re: increased obsessiveness on folate n other Bvit » Larry Hoover, posted by yxibow on February 15, 2007, at 2:16:26

> > > I tried low flushing niacin at one point as an anxiolytic experiment and it ended up making excercise uncomfortable, flushing, crankiness, and in general a complete opposite of what it is touted as.
> > >
> > > Perhaps it works for some people.
> >
> > Sorry, but you tried the wrong stuff, methinks. Low-flush niacin is usually inositol hexanicotinate. The anxiolytic form of B-3 is niacinamide (old name nicotinamide).
> >
> > Lar
> >
> >
>
> I meant sustained release, which can be low flushing.
>
> It was nicotinic acid, which is also known as B-3

So, it was a physical slow release, rather than a slowly hydrolyzed bond, but it was the wrong stuff for anxiolysis.

Nicotinic acid, a.k.a. niacin, triggers histamine release, and is stimulating at adrenoceptors. Nicotinamide, a.k.a. niacinamide, inhibits mast cell degranulation (antihistamine), and mildly agonizes GABA-A receptors. It also changes the conformation of the GABA receptor, enhancing natural GABA action.

Niacinamide is also one step closer to being converted to NADH, essential for mitochondrial energy production.

Some people, unfortunately, flush on niacinamide, due to rapid conversion to niacin. But most do not. I know people who experience anxiolysis at 100 mg, but some need 500. So long as the daily dose dose not exceed 2000 mg, there is no risk of liver toxicity.

Lar

 

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