Posted by michael on February 14, 2007, at 17:00:59
In reply to Receptor Downregulation Prevention, posted by hgi698 on February 12, 2007, at 12:44:28
As far as dopamine is concerned, you may want to take a look at Aripiprazole - I think it's a partial dopamine agonist (at D2 I think) and an antagonist (at D3 I think). I am NOT certain about this info, but may be worth a look...
michael
> Ok I have an idea about a way to possibly to prevent tolerance and potentiate the effect of amphetamine and i am looking for some feedback on this idea. Ok first you would take tetrabenazine for a little while. Tetrabenazine inhibits monamine storage in vesicles reversibly (as opposed to reserpine which is irreversible). After a period of time your post-synaptic receptors would upregulated due to reduced neurotransmitters. Then after about a week of just tetrabenazine alone, you would start a regimine taking a dose of adderall during the day, and a dose of tetrabenazine during the night. You would alternate day and night between these two doses. Now the dose might take some time to perfect. But, both adderall and tetrabenazine have a fairly short half life so it seems concievable that you could take a dose of tetrabenazine that would be completely out of your system by morning. Depleting your stores would keep your receptors at a higher level allowing the adderall to have a greater effect in the morning. So the question is does this seem like it could work?
>
> I have seen another way of preventing receptor downregulation that seems interesting as well. This method involves taking the right combination of an agonist and antagonist for the desired receptor. Apparently this method can reduce desensitization of receptors.
> See this webpage
> (http://www.freepatentsonline.com/5597699.html)
> So it seems like mixing a dopamine agonist (pramipexole/ropinirole) with a dopamine antagonist (antipsychotic) could concievably help. Maybe for serotonin mixing pindolol (5ht1a antagonist) with buspirone (5ht1a agonist) might work as well. If anyone has any input that would be great.
poster:michael
thread:732120
URL: http://www.dr-bob.org/babble/20070213/msgs/732810.html