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Re: Benzo Confidential - clonazepam's history

Posted by Squiggles on February 8, 2007, at 7:48:26

In reply to Re: Benzo Confidential - clonazepam's history » Squiggles, posted by Phillipa on February 7, 2007, at 21:18:22

> Squiggles it must have been them just kidding. Love Phillipa

Yeah, i'm not sure i got the joke.

Here's a neighbourhood find:

1: Prog Neuropsychopharmacol Biol Psychiatry. 1983;7(4-6):669-73. Links
New concepts in benzodiazepine therapy: rebound anxiety and new indications for the more potent benzodiazepines.

* Chouinard G,
* Labonte A,
* Fontaine R,
* Annable L.

Abrupt withdrawal of benzodiazepine treatment in generalized anxiety patients was found to induce a rebound anxiety state in addition to minor physical symptoms. Controlled clinical trials suggest that the newer high potency benzodiazepines (alprazolam, clonazepam and bromazepam) have novel psychiatric indications and greater anxiolytic effect than the classical benzodiazepines. Alprazolam, a triazolobenzodiazepine, was superior to placebo in the treatment of panic disorder, for which medium or low potency benzodiazepines are generally inefficacious. Clonazepam, an anticonvulsant which increases 5HT synthesis, was more efficacious than lithium in reducing manic symptoms. Bromazepam, a new potent benzodiazepine, was superior to diazepam in the treatment of generalized anxiety disorder.

PMID: 6141609 [PubMed - indexed for MEDLINE]

Dr. Chouinard seems to be the local expert on this. He shows interest in the application of benzos to various psychiatric conditions. I'm not sure if I would volunteer as a guinea pig for clonazepam monotherapy for bipolar, though he does qualify it for 'manic symptoms' and not the entire spectrum. But *that* he suggests it, at least show how exceptional clonazepam must be, not just on the grounds of its potency, but its chemical idiosyncrasy.

Squiggles



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URL: http://www.dr-bob.org/babble/20070207/msgs/731044.html