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Lexapro not working second time around

Posted by resnick on February 1, 2007, at 6:53:01

I am a long-term OCD sufferer( 10+ years ) . I have taken Prozac, Zoloft , Paxil and Lexapro in the past. Prozac and Zoloft pooped out after a while , though they worked extremely well for a couple of years each . Paxil also worked but left me very tired . I was on Lexapro for a couple of years and it was excellent, but I stopped it about 10 months back because I needed to lose weight. 4 months back, my OCD symptoms( only obsessive , no overt physical compulsions but tremendous anxiety ) returned in full swing . I started taking Zoloft but suffered horribly . Not only did it not work, but it escalated my anxiety tremendously. I stopped Zoloft after 1 and a half months and moved back to Lexapro . I take quite a high dose ( 40 mg ) but this time around, even after nearly 2 months , there is very little benefit( and I have generally responded to medicines within 3 weeks or less ) . Maybe the anxiety associated with obsessions has reduced a little, but the frequency of obsessing is still terribly high . I am quite at my wits end here.

My question to all knowledgeable people out there on this board is whether it is common for a med to lose its efficacy when stopped for a period of time and then restarted . Should I wait some more time for Lexapro to work ?

Virtually every SSRI I have taken has worked for me at least for a period of time. However , ever since the 5-6 months without drugs, things seemed to have changed. What explains this ?


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