Posted by corafree on January 26, 2007, at 13:12:02
http://www.biopsychiatry.com/dopamine.htm
Antidepressants and the dopamine connection
Measurement of D2-like binding by receptor autoradiography, using the ligand [3H]YM-09151-2, revealed that both fluoxetine and desipramine increased D2-like binding in the nucleus accumbens shell; fluoxetine had a similar effect in the nucleus accumbens core. Tranylcypromine, however, had no effect on D2-like binding in the nucleus accumbens but decreased binding in the striatum. In micro-dialysis experiments, our data showed that levels of extracellular dopamine in the nucleus accumbens were not altered in rats treated with either fluoxetine or desipramine, but increased by tranylcypromine.
Geez ... I wish we could just freeze time for oh maybe 10yrs or so. I feel there is better research going on than there may be treatment rendered presently.
What does this say in layman's terminology? :(
tksexpert, cf
poster:corafree
thread:726729
URL: http://www.dr-bob.org/babble/20070125/msgs/726729.html