Posted by yxibow on January 26, 2007, at 3:47:22
In reply to Re: Seroquel label change - increased depression?, posted by craiggetty on January 25, 2007, at 16:21:32
The labeling PI change doesn't mention Seroquel intrisically and talks about antidepressant medications as an agglutinate, a collective ("pooled analysis"). It also includes the usual adolescent may off themselves label that seems to be attached to every antidepressant these days when in fact with serious childhood MDD there can be just as equal risks untreated. Not every school rampage occurs just because a psychotic kid happens to be on Prozac, its because the parents are out to lunch and we (in the US) live in a gun happy society.
I imagine that its possible for any medication to worsen a condition but typically antipsychotics are second to lithium for rapid treatment of suicidality and depression.
While it causes other side effects that I can't tolerate at the moment, Zyprexa lifted my spirits within days. Can't say one way or the other for Seroquel but I can say in general that of course antipsychotics have a blunting effect. That blunting effect could be interpreted as disreality, which in turn is dysphoria and depression for some. Its an unfortunate side effect of all neuroleptics. But I'm not really sure whether the sedation is more "blunting" than the "blunting".
Seroquel's main problem for me is the antihistamine effect; if they could have figured how to remove the H1 from the molecule it would be quite desirable for its otherwise low side effect profile in most people.-- tidings
poster:yxibow
thread:726032
URL: http://www.dr-bob.org/babble/20070125/msgs/726602.html