Posted by psychobot5000 on January 23, 2007, at 10:56:58
In reply to Re: Anyone Taken Straterra For Depression?, posted by linkadge on January 22, 2007, at 14:42:45
> Does it give you tachycadia? Did it give you tacychardia at treatment startup. Did this resolve?
Cardiovascular effects of atomoxetine in children, adolescents, and adults.Wernicke JF, Faries D, Girod D, Brown J, Gao H, Kelsey D, Quintana H, Lipetz R, Michelson D, Heiligenstein J.
Lilly Research Laboratories, Indianapolis, Indiana, USA. jfwernicke@lilly.com
BACKGROUND: Atomoxetine is a highly specific presynaptic inhibitor of the noradrenaline (norepinephrine) transporter that was recently approved in the US for the treatment of patients with attention-deficit/hyperactivity disorder (ADHD).
RESULTS: Atomoxetine treatment was associated with small but statistically significant increases in mean systolic blood pressure in adults and diastolic blood pressure in children and adolescents. Mean pulse rate increased for all atomoxetine treatment groups. The increases in blood pressure and pulse tended to occur early in therapy, stabilised, and returned toward baseline upon drug discontinuation. There was no significant difference between atomoxetine and placebo treatment groups in change in QTcD interval for all study populations. Palpitations in the adult patient population were the only significant cardiovascular adverse event (p = 0.037) occurring more frequently in the atomoxetine treatment group (3.7%) than in the placebo group (0.8%). Discontinuations due to cardiovascular-related events were very uncommon in the adult group, and did not occur in the child/adolescent group.CONCLUSION: While atomoxetine has noradrenergic activity, increases in pulse and blood pressure were small and of little, if any, clinical significance. Atomoxetine was not associated with QT interval prolongation. Cardiovascular effects of atomoxetine were minimal, and atomoxetine was well tolerated in short- and long-term studies.
_______Sounds a little milder than with stim treatment.
poster:psychobot5000
thread:724525
URL: http://www.dr-bob.org/babble/20070119/msgs/725512.html